What are the major side effects of metformin?

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The major side effects of Metformin Hcl 500 mg, a common medication for type 2 diabetes, include gastrointestinal issues such as nausea, diarrhea, vomiting, and abdominal discomfort. Some patients may experience a metallic taste or loss of appetite. A rare but serious side effect is lactic acidosis, a condition where lactic acid builds up in the bloodstream, which can be life-threatening. Symptoms of lactic acidosis include muscle pain, difficulty breathing, fatigue, and irregular heartbeat. Vitamin B12 deficiency may also occur with long-term use. It’s important to take metformin as prescribed and consult a doctor if severe side effects develop.